There is an immediate/short term effect and an extended, longer term effect. The immediate effect generally last about 3-9 days, as the plasma is reabsorbed by the body. But the platelets and growth factors remain. They stimulate collagen and new blood vessel growth, which patient starts to notice in about 3 weeks. The effects are cumulative, so it is recommended to receive 2-3 treatments 10-12 weeks apart to achieve full effect. The full effects generally last on average 4-5 years (as this procedure reverses but does not stop the aging process).